IMDIK - Post-doctoral Research Assistant or Post-doctoral Research Associate

Mossakowski Medical Research Center, Polish Academy of Sciences, Warsaw

is seekeing a candidate for a position of Post-doctoral Research Assistant or Post-doctoral Research Associate*

* dependent on candidate’s qualifications

 

 

Recruitment is related to the project “The role of arginase 2 in the striatal function and in the pathogenesis of Huntington's disease” SONATA BIS no. 2018/30/E/NZ1/00144 pt. funded by National Science Centre, Poland,

carried out in the Laboratory of Molecular Basis of Neurodegeneration

 

 

• Scientific discipline: medical sciences
• Announcement date: November 17^th 2021
• Application deadline: December 14^th 2021
• Link to the website: www.imdik.pan.pl
• Keywords: post-doc, Huntington’s disease, neurodegeneration, protein aggregation, microscopy, metabolism, in vivo

 

The area of the research in which the candidate would participate:

The research carried out in the Laboratory of Molecular Basis of Neurodegeneration is focused at determining relationships between molecular, cellular and functional phenotypes of selected populations of the CNS cells and their susceptibility or resistance to the pathology in different neurological diseases. We are seeking a postdoctoral researcher for the project aimed at characterization of the functions of arginase 2 in the striatum (a region specifically enriched with arginase 2), with reference to the cellular and subcellular localization of this protein. The project also intends to understand the importance of arginase 2 loss for the pathogenesis of Huntington’s disease, a disorder selectively affecting striatum. The study will employ transgenic mouse models of arginase 2 loss and of Huntington’s disease, as well as a multidisciplinary experimental approach including in vivo analysis, qualitative and quantitative microscopy and targeted or large-scale protein and metabolite biochemistry techniques.

 

Description of duties:

• managing colonies of transgenic mice used in the project
• planning and conducting in vivo procedures
• designing and conducting experiments using biochemical/molecular biology/microscopic imaging techniques
• analysis of obtained data
• presenting the results at the group meetings, external seminars and scientific conferences
• preparation of scientific manuscripts
• introducing new experimental methods and establishing external collaborations to support the progress of the project
• carrying out scientific tasks in accordance with the project time schedule

 

Necessary Requirements:

• PhD degree in biological sciences, neurosciences, pharmacological sciences, medical sciences or relevant, obtained between January 1^st 2015 and December 31^st 2021
• documented scientific achievements including publications in journals from JCR list
• participation in scientific conferences and internships
• experience in laboratory techniques in biochemistry, molecular biology and histology (e.g. DNA, RNA, protein and metabolite isolation; fractionation of proteins and subcellular structures; western blot; qPCR; immunohistochemistry; stereology; enzyme activity assays; metabolite measurements (HPLC, LC-MS, NMR, ELISA, spectrophotometric/fluorometric techniques))
• experience in planning and conducting in vivo procedures (e.g. behavioral analysis, stereotactic surgeries, microdialysis)
• working knowledge of statistical software (e.g. GraphPad Prism, SPSS, R, Statistica)
• ability to work in a team and independently
• excellent knowledge of English, allowing effective communication and preparation of scientific manuscripts
• indication of Mossakowski Medical Research Centre Polish Academy of Sciences as a first place of employment

 

Desirable Requirements:

• experience in work with animal models of neurodegenerative diseases
• knowledge of techniques used in studying of protein aggregation
• experience in big data analysis

 

We offer:

• fixed term, full-time employment contract
• contract period: January 3^rd 2022 – June 30^th 2024 (The contract duration may change depending on the regulations related to COVID-19 epidemy)
• gross salary: around 8350 PLN / month
• opportunity to work in a newly established, dynamic research group
• scientific collaboration with other Polish and foreign research institutions
• opportunity to participate and present obtained results at international conferences
• scientific and administrative support in applying for grants and fellowships

 

How to Apply:

Documents should be sent to Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.. Please include the reference number (PMPN-111-1/2021) in your correspondence.

 

Required documents:

• motivation letter with description of candidate’s scientific interests, scientific work, scientific independency, participation in publications and research grants
• CV listing candidate’s education, professional experience, scientific achievements, authored or co-authored publications and conference abstracts, internships and training
• copy of the PhD (or equivalent) diploma, or a document confirming PhD defense scheduled before January 1^st 2022
• references (optionally)

 

* Depending on candidate’s qualifications, Recruitment Committee may recommend hiring a successful candidate as a Research Assistant or Research Associate

 

For more information about the project, please contact dr Michał Węgrzynowicz (Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.)

 

Expected date of the interview: December 16^th 2021 – December 17^th 2021

Expected decision date: December 20^th 2021 – December 23^rd 2021

Expected job starting date: January 3^rd 2022 (The job starting date may change depending on the regulations related to COVID-19 epidemy)

 

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