IMDIK - position of Post-doctoral Research Associate

IMDIK

Mossakowski Medical Research Institute, Polish Academy of Sciences,

is seeking a candidate for a position of Post-doctoral Research Associate

 

 

Recruitment is related to the project “Glycogen metabolism and gluconeogenesis in glomerular podocytes: impact on podocyte function in normo- and hyperglycemia.” OPUS no. 2021/41/B/NZ5/02611 funded by National Science Centre, Poland, carried out in Laboratory of Molecular and Cellular Nephrology, Gdansk, Poland.

 

City: Gdańsk

Scientific discipline: medical sciences

Announcement date: 12th May 2022

Application deadline: 10th June 2022

Link to the website: www.imdik.pan.pl

Keywords: post-doc, podocyte, hyperglycemia, diabetes, glycogen metabolism, insulin resistance.

 

The area of the research in which the candidate would participate:

Glucose homeostasis is controlled by endogenous glucose production (EGP) and glucose utilization rates. We hypothesize that the high glucose-induced impairment of insulin action may be related to enhanced EGP and glycogen accumulation in podocytes. Additionally, the energy sensing pathways crucial for metabolic control, such as the protein deacetylase, SIRT1 and AMP-dependent protein kinase (AMPK), whose activities are impaired in podocytes with HG-induced insulin resistance, may be involved in EGP modifications in these cells.

We are seeking a postdoctoral researcher for the project aimed to investigate the effects of hyperglycemia on EGP in podocytes and SIRT1-AMPK-dependent mechanism of its regulation, especially in the context of cellular energetics and insulin responsiveness.

Candidate will be involved in investigation of:

1)        glycogen metabolism in podocytes exposed to hyperglycemic conditions and its role in the regulation of podocytes energetics

2)        the role of SIRT1-AMPK-dependent regulation of glycogen metabolism in podocytes

3)        the effects of glycogen metabolism regulation on insulin signaling and glucose uptake

4)        the influence of glycogen metabolism on podocyte function

5)        the role of SIRT1-AMPK pathway in regulating glycogen metabolism in diabetic type 2 rat model

Understanding the mechanisms of the regulation of intracellular glucose homeostasis in podocytes could provide further insights into glomerular disease pathogenesis and generate novel therapeutic targets for glomerulopathy treatment in diabetes.

 

Description of duties:

  • planning and implementation of research tasks in accordance with the schedule of the project,
  • designing and conducting experiments with the use of biochemistry, molecular biology and microscopic imaging methods,
  • analysis of obtained data,
  • presenting the results at the group meetings, external seminars and scientific conferences,
  • preparation of scientific publications,

 

Necessary Requirements:

  • PhD degree in biological sciences, neurosciences, pharmacological sciences, medical sciences or relevant,
  • documented scientific achievements including publications in journals from JCR list,
  • participation in scientific conferences and internships,
  • experience in laboratory techniques in biochemistry, molecular biology (e.g. DNA, RNA, isolation; Western blot; qPCR; immunohistochemistry; spectrophotometric/fluorometric techniques),
  • ability to work in a team and independently,
  • fluent English, allowing effective communication and preparation of scientific manuscripts,
  • indication of Mossakowski Medical Research Institute Polish Academy of Sciences as a first place of employment.

 

Desirable Requirements:

  • experience in work with animal models,
  • experience in planning and conducting in vivo procedures,

 

We offer:

  • fixed term, full-time employment contract,
  • contract period: 1st July 2022 – 31st December 2025,
  • gross salary: 7880 PLN / month,
  • the opportunity to work in a pleased atmosphere, in a dynamic, developmental research group,
  • opportunity to participate and present obtained results at international conferences.

 

How to Apply:

Please send your documents to project manager: Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript. including the following job offer identification number in your application: PMKN-111-4/2022

 

Required documents:

  • motivation letter with description of candidate’s scientific interests, scientific work, scientific independency, participation in research grants,
  • CV listing candidate’s education, professional experience, scientific achievements, authored or co-authored publications and conference abstracts, internships and training,
  • copy of the PhD (or equivalent) diploma,
  • references (optionally).

 

For more information about the project, please contact dr hab. Dorota Rogacka (Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.)

 

Expected date of the interview: 13th June 2022

Expected decision date: 20th June 2022

Expected job starting date: 1st July 2022

 

 

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